“Future Cancer Research Priorities in the USA: a Lancet Oncology Commission provides a roadmap to change the course of cancer in our lifetime—a journey in which we should actively participate. Patients, caregivers, doctors, researchers, nurses, and scientists all need to embark on the course of action proposed by the report without delay.”

– Gregory Simon, President of the Biden Cancer Initiative

We are in the midst of a technological revolution that is providing new insights into human biology and cancer. In this era of big data, we are amassing large amounts of information that is transforming how we approach cancer treatment and prevention.

Enactment of the Cancer Moonshot within the 21st Century Cures Act in the USA arrived at a propitious moment in the advancement of knowledge, providing nearly US$2 billion of funding for cancer research and precision medicine. But, this money needs to be used strategically and efficiently for maximum benefit.

The US Blue Ribbon Panel (BRP) in 2016 set out a roadmap of recommendations designed to exploit new advances in cancer diagnosis, prevention, and treatment. Those recommendations provided a high-level view of how to accelerate the conversion of new scientific discoveries into effective treatments and prevention for cancer. The US National Cancer Institute is already implementing some of those recommendations.

The Lancet Oncology Commission on Future cancer research priorities in the USA builds on the BRP report. Comprising a group of 54 eminent cancer clinician–researchers representing approximately 40 institutions, BRP members, and 10 major cancer societies—the Commission unpacks the BRP recommendations in greater detail, and expands in to other priority areas, including surgical oncology, radiation oncology, imaging, health systems and health disparities, regulation and financing, population science, and oncopolicy.

The Commission recommends multiple priority areas for research in the USA that would substantially accelerate progress towards improved cancer control. Further, the Commission’s conclusions should help facilitate new international collaborations given the degree of interdependency that exists between nations.

Full list of Commission authors:

Elizabeth M Jaffee, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Chi Van Dang, Ludwig Institute for Cancer Research, New York, NY, & The Wistar Institute, Philadelphia, PA, USA
David B Agus, University of Southern California, Beverly Hills, CA, USA
Brian M Alexander, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
Kenneth C Anderson, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
Alan Ashworth, University of California San Francisco, San Francisco, CA, USA
Anna D Barker, Arizona State University, Tempe, AZ, USA
Roshan Bastani, Fielding School of Public Health and the Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA, USA
Sangeeta Bhatia, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA
Jeffrey A Bluestone, University of California San Francisco, San Francisco, CA, USA
Otis Brawley, American Cancer Society, Atlanta, GA, USA
Atul J Butte, University of California San Francisco, San Francisco, CA, USA
Daniel G Coit, Department of Surgery, Memorial Sloan-Kettering, Cancer Center, New York, NY, USA
Nancy E Davidson, Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA, USA
Mark Davis, California Institute for Technology, Pasadena, CA, USA
Ronald A DePinho, University of Texas MD Anderson Cancer Center, Houston, TX, USA
Robert B Diasio, Mayo Clinic Cancer Center, Rochester, MN, USA
Giulio Draetta, University of Texas MD Anderson Cancer Center, Houston, TX, USA
A Lindsay Frazier, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
Andrew Futreal, University of Texas MD Anderson Cancer Center, Houston, TX, USA
Sam S Gambhir, Stanford University, Stanford, CA, USA
Patricia A Ganz, Fielding School of Public Health and the Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA, USA
Levi Garraway, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
Stanton Gerson, Case Comprehensive Cancer Center, Cleveland, OH, USA
Sumit Gupta, Division of Haematology/Oncology, Hospital for Sick Children, Faculty of Medicine and IHPME, University of Toronto, Toronto, Canada
James Heath, California Institute for Technology, Pasadena, CA, USA
Ruth I Hoffman, American Childhood Cancer Organization, Beltsville, MD, USA
Cliff Hudis, Breast Cancer Medicine Service, Memorial Sloan-Kettering, Cancer Center, New York, NY, USA
Chanita Hughes-Halbert, Medical University of South Carolina and the Hollings Cancer Center, Charleston, SC, USA
Ramy Ibrahim, Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA
Hossein Jadvar, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Brian Kavanagh, Department of Radiation Oncology, University of Colorado, Denver, CO, USA
Rick Kittles, College of Medicine and the University of Arizona Cancer Center, University of Arizona, Tucson, AZ, USA
Quynh-Thu Le, Stanford University, Stanford, CA, USA
Scott M Lippman, University of California, San Diego Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA
David Mankoff, Department of Radiology and Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Elaine R Mardis, The Institute for Genomic Medicine at Nationwide Children’s Hospital Columbus, OH, USA
Deborah K Mayer, University of North Carolina, Lineberger Cancer Center, Chapel Hill, NC, USA
Kelly McMasters, The Hiram C Polk Jr MD Department of Surgery, University of Louisville School of Medicine, Louisville, KY, USA
Neal J Meropol, Flatiron Health, New York, NY, USA
Beverly Mitchell, Stanford University, Stanford, CA, USA
Peter Naredi, Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Dean Ornish, University of California San Francisco, San Francisco, CA, USA
Timothy M Pawlik, Department of Surgery, Wexner Medical Center, Ohio State University, Columbus, OH, USA
Jeffrey Peppercorn, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Martin G Pomper, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Derek Raghavan, Levine Cancer Institute, Carolinas HealthCare, Charlotte, NC, USA
Christine Ritchie, University of California San Francisco, San Francisco, CA, USA
Sally W Schwarz, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA
Richard Sullivan, King’s College London, London, UK
Richard Wahl, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA
Jedd D Wolchok, Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA
Sandra L Wong, Department of Surgery,The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA
Alfred Yung, University of Texas MD Anderson Cancer Center, Houston, TX, USA